Garritsen O, van Battum EY, Grossouw LM, Pasterkamp RJ (2023). Development, wiring and function of dopamine neuron subtypes. Nat Rev Neurosci 24, 134-152.
Bassil K, Krontira AC, Leroy T, Escoto AIH, Snijders C, Pernia CD, Pasterkamp RJ, de Nijs L, van den Hove D, Kenis G, Boks MP, Vadodaria K, Daskalakis NP, Binder EB, Rutten BPF (2023). In vitro modeling of the neurobiological effects of glucocorticoids: A review. Neurobiol Stress 23, 100530.
Seeler S, Andersen MS, Sztanka-Toth T, Rybiczka-Tešulov M, van den Munkhof MH, Chang CC, Maimaitili M, Venø MT, Hansen TB, Pasterkamp RJ, Rybak-Wolf A, Denham M, Rajewsky N, Kristensen LS, Kjems J (2023). A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development. Mol Neurobiol 60, 3239-3260.
Willemse SW, Harley P, van Eijk RPA, Demaegd KC, Zelina P, Pasterkamp RJ, van Damme P, Ingre C, van Rheenen W, Veldink JH, Kiernan MC, Al-Chalabi A, van den Berg LH, Fratta P, van Es MA (2023). UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic target. J Neurol Neurosurg Psychiatry, jnnp-2022-330504.
Dumas DB, Gornati SV, Adolfs Y, Shimogori T, Pasterkamp RJ, Hoebeek FE (2022). Anatomical Development of the Cerebellothalamic Tract in Embryonic Mice. Cells 11, 3800.
van de Haar LL, Riga D, Boer JE, Garritsen O, Adolfs Y, Sieburgh TE, van Dijk RE, Watanabe K, van Kronenburg NCH, Broekhoven MH, Posthuma D, Meye FJ, Basak O, Pasterkamp RJ (2022). Molecular signatures and cellular diversity during mouse habenula development. Cell Rep 40, 111029.
Berdenis van Berlekom A, Kübler R, Hoogeboom JW, Vonk D, Sluijs JA, Pasterkamp RJ, Middeldorp J, Kraneveld AD, Garssen J, Kahn RS, Hol EM, de Witte LD, Boks MP (2022). Exposure to the Amino Acids Histidine, Lysine, and Threonine Reduces mTOR Activity and Affects Neurodevelopment in a Human Cerebral Organoid Model. Nutrients. 14, 2175.
Gomes-Duarte A, Venø MT, de Wit M, Senthilkumar K, Broekhoven MH, van den Herik J, Heeres FR, van Rossum D, Rybiczka-Tesulov M, Legnini I, van Rijen PC, van Eijsden P, Gosselaar PH, Rajewsky N, Kjems J, Vangoor VR, Pasterkamp RJ (2022). Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology. Front Mol Neurosci 15:832133.
Donega V, van der Geest AT, Sluijs JA, van Dijk RE, Wang CC, Basak O, Pasterkamp RJ, Hol EM (2022) Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors. Nat Commun 13(1):1036.
Hol EM, Pasterkamp RJ (2022) Microglial transcriptomics meets genetics: new disease leads. Nat Rev Neurol 18, 191-192.
Nielsen AF, Bindereif A, Bozzoni I, Hanan M, Hansen TB, Irimia M, Kadener S, Kristensen LS, Legnini I, Morlando M, Jarlstad Olesen MT, Pasterkamp RJ, Preibisch S, Rajewsky N, Suenkel C, Kjems J (2022). Best practice standards for circular RNA research. Nat Methods 19,1208-1220.
Bonapersona V, Schuler H, Damsteegt R, Adolfs Y, Pasterkamp RJ, van den Heuvel MP, Joëls M, Sarabdjitsingh RA (2022). The mouse brain after foot shock in four dimensions: Temporal dynamics at a single-cell resolution. Proc Natl Acad Sci U S A 119(8):e2114002119.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng HJ, Tazelaar GHP, van Eijk KR, Moisse M, Baird D, Al Khleifat A, Iacoangeli A, Ticozzi N, Ratti A, Cooper-Knock J, Morrison KE, Shaw PJ, Basak AN, Chiò A, Calvo A, Moglia C, Canosa A, Brunetti M, Grassano M, Gotkine M, Lerner Y, Zabari M, Vourc’h P, Corcia P, Couratier P, Mora Pardina JS, Salas T, Dion P, Ross JP, Henderson RD, Mathers S, McCombe PA, Needham M, Nicholson G, Rowe DB, Pamphlett R, Mather KA, Sachdev PS, Furlong S, Garton FC, Henders AK, Lin T, Ngo ST, Steyn FJ, Wallace L, Williams KL; BIOS Consortium; Brain MEND Consortium, Neto MM, Cauchi RJ, Blair IP, Kiernan MC, Drory V, Povedano M, de Carvalho M, Pinto S, Weber M, Rouleau GA, Silani V, Landers JE, Shaw CE, Andersen PM, McRae AF, van Es MA, Pasterkamp RJ, Wray NR, McLaughlin RL, Hardiman O, Kenna KP, Tsai E, Runz H, Al-Chalabi A, van den Berg LH, Van Damme P, Mill J, Veldink JH, Heijmans BT, T Hoen PAC, van Meurs J, Jansen R, Franke L, Boomsma DI, Pool R, van Dongen J, Hottenga JJ, van Greevenbroek MMJ, Stehouwer CDA, van der Kallen CJH, Schalkwijk CG, Wijmenga C, Franke L, Zhernakova S, Tigchelaar EF, Slagboom PE, Beekman M, Deelen J, van Heemst D, Veldink JH, van den Berg LH, van Duijn CM, Hofman BA, Isaacs A, Uitterlinden AG, van Meurs J, Jhamai PM, Verbiest M, Suchiman HED, Verkerk M, van der Breggen R, van Rooij J, Lakenberg N, Mei H, van Iterson M, van Galen M, Bot J, Zhernakova DV, Jansen R, van ‘t Hof P, Deelen P, Nooren I, T Hoen PAC, Heijmans BT, Moed M, Franke L, Vermaat M, Zhernakova DV, Luijk R, Jan Bonder M, van Iterson M, Deelen P, van Dijk F, van Galen M, Arindrarto W, Kielbasa SM, Swertz MA, van Zwet EW, Jansen R, T Hoen PAC, Heijmans BT, Al-Chalabi A, Wray NR, Bensimon G, Hardiman O, Chio A, Veldink JH, Smith GD, Mill J (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Sci Transl Med 14(633):eabj0264.
Tomris I, Bouwman KM, Adolfs Y, Noack D, van der Woude R, Kerster G, Herfst S, Sanders RW, van Gils MJ, Boons GJ, Haagmans BL, Pasterkamp RJ, Rockx B, de Vries RP. Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns. PLoS Pathog. 18(3):e1010340.
Siqueira E, Obiols-Guardia A, Jorge-Torres OC, Oliveira-Mateos C, Soler M, Ramesh-Kumar D, Setién F, van Rossum D, Pascual-Alonso A, Xiol C, Ivan C, Shimizu M, Armstrong J, Calin GA, Pasterkamp RJ, Esteller M, Guil S (2021) Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome. Mol Ther Nucleic Acids 27, 621-644.
van der Vlist M, Raoof R, Willemen HLDM, Prado J, Versteeg S, Martin Gil C, Vos M, Lokhorst RE, Pasterkamp RJ, Kojima T, Karasuyama H, Khoury-Hanold W, Meyaard L, Eijkelkamp N (2021) Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain. Neuron S0896-6273(21)00969-7.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra HJ, Bakker OB, Deelen P, Shireby G, Hannon E, Moisse M, Baird D, Restuadi R, Dolzhenko E, Dekker AM, Gawor K, Westeneng HJ, Tazelaar GHP, van Eijk KR, Kooyman M, Byrne RP, Doherty M, Heverin M, Al Khleifat A, Iacoangeli A, Shatunov A, Ticozzi N, Cooper-Knock J, Smith BN, Gromicho M, Chandran S, Pal S, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Sendtner M, Meyer T, Başak N, van der Kooi AJ, Ratti A, Fogh I, Gellera C, Lauria G, Corti S, Cereda C, Sproviero D, D’Alfonso S, Sorarù G, Siciliano G, Filosto M, Padovani A, Chiò A, Calvo A, Moglia C, Brunetti M, Canosa A, Grassano M, Beghi E, Pupillo E, Logroscino G, Nefussy B, Osmanovic A, Nordin A, Lerner Y, Zabari M, Gotkine M, Baloh RH, Bell S, Vourc’h P, Corcia P, Couratier P, Millecamps S, Meininger V, Salachas F, Mora Pardina JS, Assialioui A, Rojas-García R, Dion PA, Ross JP, Ludolph AC, Weishaupt JH, Brenner D, Freischmidt A, Bensimon G, Brice A, Durr A, Payan CAM, Saker-Delye S, Wood NW, Topp S, Rademakers R, Tittmann L, Lieb W, Franke A, Ripke S, Braun A, Kraft J, Whiteman DC, Olsen CM, Uitterlinden AG, Hofman A, Rietschel M, Cichon S, Nöthen MM, Amouyel P; SLALOM Consortium; PARALS Consortium; SLAGEN Consortium; SLAP Consortium, Traynor BJ, Singleton AB, Mitne Neto M, Cauchi RJ, Ophoff RA, Wiedau-Pazos M, Lomen-Hoerth C, van Deerlin VM, Grosskreutz J, Roediger A, Gaur N, Jörk A, Barthel T, Theele E, Ilse B, Stubendorff B, Witte OW, Steinbach R, Hübner CA, Graff C, Brylev L, Fominykh V, Demeshonok V, Ataulina A, Rogelj B, Koritnik B, Zidar J, Ravnik-Glavač M, Glavač D, Stević Z, Drory V, Povedano M, Blair IP, Kiernan MC, Benyamin B, Henderson RD, Furlong S, Mathers S, McCombe PA, Needham M, Ngo ST, Nicholson GA, Pamphlett R, Rowe DB, Steyn FJ, Williams KL, Mather KA, Sachdev PS, Henders AK, Wallace L, de Carvalho M, Pinto S, Petri S, Weber M, Rouleau GA, Silani V, Curtis CJ, Breen G, Glass JD, Brown RH Jr, Landers JE, Shaw CE, Andersen PM, Groen EJN, van Es MA, Pasterkamp RJ, Fan D, Garton FC, McRae AF, Davey Smith G, Gaunt TR, Eberle MA, Mill J, McLaughlin RL, Hardiman O, Kenna KP, Wray NR, Tsai E, Runz H, Franke L, Al-Chalabi A, Van Damme P, van den Berg LH, Veldink JH (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet. 53, 1636-1648.
Varderidou-Minasian S, Verheijen BM, Harschnitz O, Kling S, Karst H, van der Pol WL, Pasterkamp RJ, Altelaar M (2021) Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Display Altered Proteomes at Early Stages of Differentiation. ACS Omega 6, 35375-35388.
Raoof R, Martin Gil C, Lafeber FPJG, de Visser H, Prado J, Versteeg S, Pascha MN, Heinemans ALP, Adolfs Y, Pasterkamp J, Wood JN, Mastbergen SC, Eijkelkamp N (2021). Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain. J Neurosci 41, 8249-8261.
Budding K, Johansen LE, Van de Walle I, Dijkxhoorn K, de Zeeuw E, Bloemenkamp LM, Bos JW, Jansen MD, Curial CAD, Silence K, de Haard H, Blanchetot C, Van de Ven L, Leusen JHW, Pasterkamp RJ, van den Berg LH, Hack CE, Boross P, van der Pol WL (2021). Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy. Neurol Neuroimmunol Neuroinflamm 9, e1107.
Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malnauskaite L, Brignani S, van den Munkhof M, Düdükcü Ö, de Ruiter AA, van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ*, Siebold C* (2021) Simultaneous binding of guidance cues NET1 and RGM blocks extracellular NEO1 signaling (2021) Cell 184, 2103-2120.
Spijkers XM, Pasteuning-Vuhman S, Dorleijn JC, Vulto P, Wevers NR, Pasterkamp RJ (2021). A directional 3D neurite outgrowth model for studying motor axon biology and disease. Sci Rep 11: 2080.
Perez-Pardo P, Grobben Y, Willemsen-Seegers N, Hartog M, Tutone M, Muller M, Adolfs Y, Pasterkamp RJ, Vu-Pham D, van Doornmalen AM, van Cauter F, de Wit J, Sterrenburg JG, Uitdehaag JCM, de Man J, Buijsman RC, Zaman GJR, Kraneveld AD (2021). Pharmacological validation of TDO as a target for Parkinson’s disease. FEBS J. doi: 10.1111/febs.15721. Online ahead of print.
Klein R, Pasterkamp RJ (2020). Recent advances in inter-cellular interactions during neural circuit assembly. Curr Opin Neurobiol 69:25-32.
de Jongh R, Spijkers XM, Pasteuning-Vuhman S, Vulto P, Pasterkamp RJ (2020). Neuromuscular Junction-on-a-Chip: ALS disease modeling and read-out development in microfluidic devices. J Neurochem, doi: 10.1111/jnc.15289. Online ahead of print.
Genzel L, Adan R, Berns A, van den Beucken JJJP, Blokland A, Boddeke EHWGM, Bogers WM, Bontrop R, Bulthuis R, Bousema T, Clevers H, Coenen TCJJ, van Dam AM, Deen PMT, van Dijk KW, Eggen BJL, Elgersma Y, Erdogan I, Englitz B, Fentener van Vlissingen JM, la Fleur S, Fouchier R, Fitzsimons CP, Frieling W, Haagmans B, Heesters BA, Henckens MJAG, Herfst S, Hol E, van den Hove D, de Jonge MI, Jonkers J, Joosten LAB, Kalsbeek A, Kamermans M, Kampinga HH, Kas MJ, Keijer J, Kersten S, Kiliaan AJ, Kooij TWA, Kooijman S, Koopman WJH, Korosi A, Krugers HJ, Kuiken T, Kushner SA, Langermans JAM, Lesscher HMB, Lucassen PJ, Lutgens E, Netea MG, Noldus LPJJ, van der Meer JWM, Meye FJ, Mul JD, van Oers K, Olivier JDA, Pasterkamp RJ, Philippens IHCHM, Prickaerts J, Pollux BJA, Rensen PCN, van Rheenen J, van Rij RP, Ritsma L, Rockx BHG, Roozendaal B, van Schothorst EM, Stittelaar K, Stockhofe N, Swaab DF, de Swart RL, Vanderschuren LJMJ, de Vries TJ, de Vrij F, van Wezel R, Wierenga CJ, Wiesmann M, Willuhn I, de Zeeuw CI, Homberg JR (2020). How the COVID-19 pandemic highlights the necessity of animal research. Curr Biol 30, 4328.
Pasteuning-Vuhman S, de Jongh R, Timmers A, Pasterkamp RJ (2020). Towards Advanced iPSC-based Drug Development for Neurodegenerative Disease. Trends Mol Med S1471-4914(20)30260-4.
Pasterkamp RJ*, Burk K* (2020). Axon guidance receptors: Endocytosis, trafficking and downstream signaling from endosomes. Prog Neurobiol, doi: 10.1016/j.pneurobio.2020.101916. Online ahead of print.
Vangoor VR, Gomes-Duarte A, Pasterkamp RJ (2020). Long non-coding RNAs in motor neuron development and disease. J Neurochem, doi: 10.1111/jnc.15198. Online ahead of print.
Tazelaar GHP, Boeynaems S, De Decker M, van Vugt JJFA, Kool L, Goedee HS, McLaughlin RL, Sproviero W, Iacoangeli A, Moisse M, Jacquemyn M, Daelemans D, Dekker AM, van der Spek RA, Westeneng HJ, Kenna KP, Assialioui A, Da Silva N; Project MinE ALS Sequencing Consortium, Povedano M, Pardina JSM, Hardiman O, Salachas F, Millecamps S, Vourc’h P, Corcia P, Couratier P, Morrison KE, Shaw PJ, Shaw CE, Pasterkamp RJ, Landers JE, Van Den Bosch L, Robberecht W, Al-Chalabi A, van den Berg LH, Van Damme P, Veldink JH, van Es MA (2020) ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Commun 2, fcaa064.
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups (2020). LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 587, 377-386.
Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz-Rodriguez A, Muilu J, Fabene PF, Pasterkamp RJ, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J, Henshall DC (2020). A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. Proc Natl Acad Sci U S A 117, 15977-15988.
Brignani S, Raj DDA, Schmidt ERE, Düdükcü Ö, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chédotal A, Pasterkamp RJ (2020). Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron 107, 684-702.
Soleilhavoup C, Travaglio M, Patrick K, Garção P, Boobalan E, Adolfs Y, Spriggs RV, Moles-Garcia E, Dhiraj D, Oosterveen T, Ferri SL, Abel T, Brodkin ES, Pasterkamp RJ, Brooks BP, Panman L (2020). Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun 11, 3111.
Rozbesky D, Verhagen MG, Karia D, Nagy GN, Alvarez L, Robinson RA, Harlos K, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2020). Structural basis of semaphorin-plexin cis interaction. EMBO J 39, e102926.
Schijven D, Stevelink R, McCormack M, van Rheenen W, Luykx JJ, Koeleman BPC, Veldink JH; Project MinE ALS GWAS Consortium; International League Against Epilepsy Consortium on Complex Epilepsies (2020). Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiol Aging 92, 153.e1-153.e5.
Varderidou-Minasian S, Verheijen BM, Schätzle P, Hoogenraad CC, Pasterkamp RJ, Altelaar M (2020). Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells. J Proteome Res 19, 2391-2403.
Wu B, Blot FG, Wong AB, Osório C, Adolfs Y, Pasterkamp RJ, Hartmann J, Becker EB, Boele HJ, De Zeeuw CI, Schonewille M (2019). TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells. Elife e45590.
De Santis R, Alfano V, de Turris V, Colantoni A, Santini L, Garone MG, Antonacci G, Peruzzi G, Sudria-Lopez E, Wyler E, Anink JJ, Aronica E, Landthaler M, Pasterkamp RJ, Bozzoni I, Rosa A (2019). Mutant FUS and ELAVL4 (huD) aberrant crosstalk in Amyotrophic lateral sclerosis. Cell Rep 27, 3818-3831.
Markworth R, Adolfs Y, Dambeck V, Steinbeck LM, Lizé M, Pasterkamp RJ, Bähr M, Dean C, Burk K (2019). Sensory axon growth requires spatiotemporal integration of CaSR and TrkB signaling. J Neurosci 39, 5842-5860.
Zelina P, Pasterkamp RJ (2019) Axons navigate noise with p190RhoGAP. Neuron 102, 512-514.
Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ (2019). Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures. J Neurosci 39, 5064-5079.
Riemslagh FW, Lans H, Seelaar H, Severijnen LWFM, Melhem S, Vermeulen W, Aronica E, Pasterkamp RJ, van Swieten JC, Willemsen R (2019). HR23B pathology preferentially co-localizes with p62, pTDP-43 and ploy-GA in C9)RF72-linked frontotemporal dementia and amyotrophic lateral sclerosis. Acta Neuropathol Commun 7, 39.
Burk K, Pasterkamp RJ (2019). Disrupted neuronal trafficking in amyotrophic lateral sclerosis. Acta Neuropathol 137, 859-877.
Ormel PR, Vieira de Sá R, van Bodegraven EJ, Karst H, Harschnitz O, Sneeboer MAM, Johansen LE, van Dijk RE, Scheefhals N, Berdenis van Berlekom A, Ribes Martínez E, Kling S, MacGillavry HD, van den Berg LH, Kahn RS, Hol EM, de Witte LD, Pasterkamp RJ (2018) Microglia innately develop within cerebral organoids. Nature Commun 9, 4167.
Frick P, Sellier C, Mackenzie IRA, Cheng CY, Tahraoui-Bories J, Martinat C, Pasterkamp RJ, Prudlo J, Edbauer D, Oulad-Abdelghani M, Feederle R, Charlet-Berguerand N, Neumann M (2018) Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers. Acta Neuropathol Commun 6, 72.
Cunha-Ferreira I, Chazeau A, Buijs RR, Stucchi R, Will L, Pan X, Adolfs Y, van der Meer C, Wolthuis JC, Kahn OI, Schätzle P, Altelaar M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC (2018) The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development. Cell Rep 24(4):791-800.
Dazzo E, Rehberg K, Michelucci R, Passarelli D, Boniver C, Vianello Dri V, Striano P, Striano S, Pasterkamp RJ, Nobile C (2018) Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy. Ann Neurol 83, 483-493.
Verheijen BM, Pasterkamp RJ (2018) Commentary: FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Front Mol Neurosci 10:412.
Shi Y, Lin S, Staats KA, Li Y, Chang W-H, Hung S-T, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng T-Y, Lee S-JJ, August P, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BZ, Ichida JK (2017) Haploinsufficiency Leads to Neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature Med 24, 313-325.
van Battum EY, Verhagen MG, Vangoor VR, Fujita Y, Derijck AAHA, O’Duibhir E, Giuliani G, de Gunst T, Adolfs Y, Lelieveld D, Egan D, Schaapveld RQJ, Yamashita T, Pasterkamp RJ (2017) An Image-Based miRNA screen identifies miRNA-135s as regulators of CNS axon growth and regeneration by targeting Krüppel-like factor 4. J Neurosci 38, 613-630.
Braccioli L, Vervoort SJ, Adolfs Y, Heijnen CJ, Basak O, Pasterkamp RJ, Nijboer CH, Coffer PJ (2017) FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression. Stem Cell Reports 9, 1530-1545.
Chabrat A, Brisson G, Doucet-Beaupré H, Salesse C, Schaan Profes M, Dovonou A, Akitegetse C, Charest J, Lemstra S, Côté D, Pasterkamp RJ, Abrudan MI, Metzakopian E, Ang SL, Lévesque M (2017) Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation. Nature Commun 8, 933.
Rademacher S, Verheijen BM, Hensel N, Peters M, Bora G, Brandes G, Vieira de Sá R, Heidrich N, Fischer S, Brinkmann H, van der Pol WL, Wirth B, Pasterkamp RJ, Claus P (2017) Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease spinal muscular atrophy (SMA). Hum Mol Genet 26(20):3946-3959.
Schmidt ERE, Pasterkamp RJ (2017) The molecular mechanisms controlling morphogenesis and wiring of the habenula. Pharmacol Biochem Behav 162, 29-37.
Korecka JA, Moloney EB, Eggers R, Hobo B, Scheffer S, Ras-Verloop N, Pasterkamp RJ, Swaab DF, Smit AB, van Kesteren RE, Bossers K, Verhaagen J (2017) Repulsive Guidance Molecule a (RGMa) Induces Neuropathological and Behavioral Changes That Closely Resemble Parkinson’s Disease. J Neurosci 37, 9361-9379.
Mills JD, Iyer AM, van Scheppingen J, Bongaarts A, Anink JJ, Janssen B, Zimmer TS, Spliet WG, van Rijen PC, Jansen FE, Feucht M, Hainfellner JA, Krsek P, Zamecnik J, Kotulska K, Jozwiak S, Jansen A, Lagae L, Curatolo P, Kwiatkowski DJ, Pasterkamp RJ, Senthilkumar K, von Oerthel L, Hoekman MF, Gorter JA, Crino PB, Mühlebner A, Scicluna BP, Aronica E (2017) Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment. Sci Rep 7, 8089.
Brignani S, Pasterkamp RJ (2017) Neuronal Subset-Specific Migration and Axonal Wiring Mechanisms in the Developing Midbrain Dopamine System. Front Neuroanat 11, 55.
van Es MA, Hardiman O, Chio A, Al-Chalabi A, Pasterkamp RJ, Veldink JH, van den Berg LH (2017) Amyotrophic lateral sclerosis. Lancet 390, 2084-2098.
Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC (2017) Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron 94, 809-825.e7.
Harterink M, da Silva ME, Will L, Turan J, Ibrahim A, Lang AE, van Battum EY, Pasterkamp RJ, Kapitein LC, Kudryashov D, Barres BA, Hoogenraad CC, Zuchero JB (2017) DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells. Nature Methods 14, 479-482.
McLaughlin RL, Schijven D, van Rheenen W, van Eijk KR, O’Brien M, Kahn RS, Ophoff RA, Goris A, Bradley DG, Al-Chalabi A, van den Berg LH, Luykx JJ, Hardiman O, Veldink JH; Project MinE GWAS Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium (2017) Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature Commun 8, 14774.
Jongbloets BC, Lemstra S, Schellino R, Broekhoven MH, Parkash J, Hellemons AJ, Mao T, Giacobini P, van Praag H, De Marchis S, Ramakers GM, Pasterkamp RJ (2017) Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nature Commun 8:14666.
Venø MT, Venø ST, Rehberg K, van Asperen JV, Clausen BH, Holm IE, Pasterkamp RJ, Finsen B, Kjems J (2017) Cortical Morphogenesis during Embryonic Development Is Regulated by miR-34c and miR-204. Front Mol Neurosci 10, 31.
Middelkamp S, van Heesch S, Braat AK, de Ligt J, van Iterson M, Simonis M, van Roosmalen MJ, Kelder MJ, Kruisselbrink E, Hochstenbach R, Verbeek NE, Ippel EF, Adolfs Y, Pasterkamp RJ, Kloosterman WP, Kuijk EW, Cuppen E (2017) Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells. Genome Med 9, 9.
Siebold C, Yamashita T, Monnier PP, Mueller BK, Pasterkamp RJ (2017). RGMs: Structural insights, molecular regulation and downstream signaling. Trends in Cell Biology 27, 365-378.
Engelen-Lee Y, Blokhuis AM, Spliet WGM, Pasterkamp RJ, Aronica E, Demmers JAA, Broekhuizen R, Nardo G, Bovenschen N, Van den Berg LH (2017). Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis. ALS Frontotemp Degeneration 18, 210-220.
Zuko A, Aguro-Ando A, Post H, Taggenbrock RLRE, Van Dijk RE, Altelaar M, Heck AJR, Petrenko AG, Van der Zwaag B, Shimoda Y, Pasterkamp RJ, Burbach JPH (2017) Association of cell adhesion molecules contactin-6 and latrophilin-1 regulates neuronal apoptosis. Front Mol Neuroscience 9, 143.
Reschke CR, LFA Silva , Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O’Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC (2017). Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy. Mol Therapy – Nucl Acids 6, 45-56.
Pronker MF, Lemstra S, Snijder J, Heck AJR, Thies-Weesie DME, Pasterkamp RJ, Janssen BJC (2016). Structural basis of myelin-associated glycoprotein adhesion and signalling. Nature Communications 7, 13584.
Siebold C, Yamashita T, Monnier PP, Mueller BK, Pasterkamp RJ (2016). RGMs: Structural insights, molecular regulation and downstream signaling. Trends in Cell Biology, in press.
Engelen-Lee Y, Blokhuis AM, Spliet WGM, Pasterkamp RJ, Aronica E, Demmers JAA, Broekhuizen R, Nardo G, Bovenschen N, Van den Berg LH (2016). Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis. ALS Frontotemp Degeneration, in press.
Zuko A, Aguro-Ando A, Post H, Taggenbrock RLRE, Van Dijk RE, Altelaar M, Heck AJR, Petrenko AG, Van der Zwaag B, Shimoda Y, Pasterkamp RJ, Burbach JPH (2016) Association of cell adhesion molecules contactin-6 and latrophilin-1 regulates neuronal apoptosis. Front Mol Neuroscience, in press.
Reschke CR, LFA Silva , Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O’Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC (2016). Potent anti-seizure effects of locked nucleic acid antagomirs targeting miR-134 in multiple mouse and rat models of epilepsy. Mol Therapy – Nucl Acids, in press.
Pronker MF, Lemstra S, Snijder J, Heck AJR, Thies-Weesie DME, Pasterkamp RJ, Janssen BJC (2016). Structural basis of myelin-associated glycoprotein adhesion and signalling. Nature Communications 7, 13584. .
Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JH, Schorge S, Lamottke K, Rosenow F (2016). MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurology 15, 1368-1376.
Schellino R, Trova S, Cimino I, Farinetti A, Jongbloets BC, Pasterkamp RJ, Panzica G, Giacobini P, De Marchis S, Peretto P (2016). Opposite-sex attraction in male mice requires testosterone-dependent regulation of adult olfactory bulb neurogenesis. Sci Rep 6, 36063.
van Rossum D, Verheijen BM, Pasterkamp RJ (2016). Circular RNAs: Novel Regulators of Neuronal Development. Front Mol Neurosci 9, 74.
van Rheenen W, Shatunov A, Dekker AM, McLaughlin RL, Diekstra FP, Pulit SL, van der Spek RA, Võsa U, de Jong S, Robinson MR, Yang J, Fogh I, van Doormaal PT, Tazelaar GH, Koppers M, Blokhuis AM, Sproviero W, Jones AR, Kenna KP, van Eijk KR, Harschnitz O, Schellevis RD, Brands WJ, Medic J, Menelaou A, Vajda A, Ticozzi N, Lin K, Rogelj B, Vrabec K, Ravnik-Glavač M, Koritnik B, Zidar J, Leonardis L, Grošelj LD, Millecamps S, Salachas F, Meininger V, de Carvalho M, Pinto S, Mora JS, Rojas-García R, Polak M, Chandran S, Colville S, Swingler R, Morrison KE, Shaw PJ, Hardy J, Orrell RW, Pittman A, Sidle K, Fratta P, Malaspina A, Topp S, Petri S, Abdulla S, Drepper C, Sendtner M, Meyer T, Ophoff RA, Staats KA, Wiedau-Pazos M, Lomen-Hoerth C, Van Deerlin VM, Trojanowski JQ, Elman L, McCluskey L, Basak AN, Tunca C, Hamzeiy H, Parman Y, Meitinger T, Lichtner P, Radivojkov-Blagojevic M, Andres CR, Maurel C, Bensimon G, Landwehrmeyer B, Brice A, Payan CA, Saker-Delye S, Dürr A, Wood NW, Tittmann L, Lieb W, Franke A, Rietschel M, Cichon S, Nöthen MM, Amouyel P, Tzourio C, Dartigues JF, Uitterlinden AG, Rivadeneira F, Estrada K, Hofman A, Curtis C, Blauw HM, van der Kooi AJ, de Visser M, Goris A, Weber M, Shaw CE, Smith BN, Pansarasa O, Cereda C, Del Bo R, Comi GP, D’Alfonso S, Bertolin C, Sorarù G, Mazzini L, Pensato V, Gellera C, Tiloca C, Ratti A, Calvo A, Moglia C, Brunetti M, Arcuti S, Capozzo R, Zecca C, Lunetta C, Penco S, Riva N, Padovani A, Filosto M, Muller B, Stuit RJ; PARALS Registry.; SLALOM Group.; SLAP Registry.; FALS Sequencing Consortium.; SLAGEN Consortium.; NNIPPS Study Group., Blair I, Zhang K, McCann EP, Fifita JA, Nicholson GA, Rowe DB, Pamphlett R, Kiernan MC, Grosskreutz J, Witte OW, Ringer T, Prell T, Stubendorff B, Kurth I, Hübner CA, Leigh PN, Casale F, Chio A, Beghi E, Pupillo E, Tortelli R, Logroscino G, Powell J, Ludolph AC, Weishaupt JH, Robberecht W, Van Damme P, Franke L, Pers TH, Brown RH, Glass JD, Landers JE, Hardiman O, Andersen PM, Corcia P, Vourc’h P, Silani V, Wray NR, Visscher PM, de Bakker PI, van Es MA, Pasterkamp RJ, Lewis CM, Breen G, Al-Chalabi A, van den Berg LH, Veldink JH (2016). Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genet 48, 1043-8.
Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ*, Jones EY* (2016). Structural Basis for Plexin Activation and Regulation. Neuron 91, 548-60. *Shared senior authors. Preview in Neuron.
Sudria-Lopez E, Koppers M, de Wit M, van der Meer C, Westeneng HJ, Zundel CA, Youssef SA, Harkema L, de Bruin A, Veldink JH, van den Berg LH, Pasterkamp RJ (2016). Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects. Acta Neuropathol 132, 145-7.
Blokhuis AM, Koppers M, Groen EJ, van den Heuvel DM, Dini Modigliani S, Anink JJ, Fumoto K, van Diggelen F, Snelting A, Sodaar P, Verheijen BM, Demmers JA, Veldink JH, Aronica E, Bozzoni I, den Hertog J, van den Berg LH, Pasterkamp RJ (2016). Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways. Acta Neuropathol 132, 175-96.
Harschnitz O, van den Berg LH, Johansen LE, Jansen MD, Kling S, Vieira de Sá R, Vlam L, van Rheenen W, Karst H, Wierenga CJ, Pasterkamp RJ*, van der Pol WL* (2016). Autoantibody pathogenicity in a multifocal motor neuropathy induced pluripotent stem cell-derived model. Ann Neurol 80, 71-88. *Shared senior authors.
van Es MA, Kruitwagen-van Reenen ET, Schröder CD, Pasterkamp RJ, Veldink JH, van den Berg LH (2016). Amyotrophic lateral sclerosis, a heterogeneous disorder. Ned Tijdschr Geneeskd 160, A9658.
Van Rijn A, Paulis L, Te Riet J, Vasaturo A, Reinieren-Beeren I, van der Schaaf A, Kuipers AJ, Schulte LP, Jongbloets BC, Pasterkamp RJ, Figdor CG, van Spriel AB, Buschow SI (2015). Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration. J Immunol 196, 459-468.
Dekker AM, Seelen M, van Doormaal PT, van Rheenen W, Bothof RJ, van Riessen T, Brands WJ, van der Kooi AJ, de Visser M, Voermans NC, Pasterkamp RJ, Veldink JH, van den Berg LH, van Es MA (2015) Large-scale screening in sporadic amyotrophic lateral sclerosis identifies genetic modifiers in C9orf72 repeat carriers. Neurobiol Aging 39, 220.e9-15.
Van Erp S, van den Heuvel DMA, Fujita Y, Robinson R, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers J, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ (2015) Lrig2 negatively regulates ectodomain shedding of axon guidance receptors by ADAM proteases. Dev Cell 35, 537-552. F1000
Van Beuningen SFB, Will L, Harterink M, Chazeau A, van Battum EY, Frias CP, Franker MAM, Katrukha EA, Stucchi R, Vocking K, Antunes AT, Slenders L, Doulkeridou S, Sillevis Smitt P, Altelaar MAF, Post JA, Akhmanova A, Pasterkamp RJ, Kapitein LC, de Graaff E, Hoogenraad CC (2015) TRIM46 controls neuronal polarity and axon specification by driving the formation of parallel microtubule arrays. Neuron 88, 1208-1226.
Morello F, Prasad AA, Rehberg K, Vieira de Sá R, Antón-Bolaños N, Leyva-Diaz E, Adolfs Y, Tissir F, López-Bendito G, Pasterkamp RJ (2015) Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development. J Neurosci 35, 14205-19.
Koppers M, Blokhuis AM, Westeneng HJ, Terpstra ML, Zundel CA, Vieira de Sá R, Schellevis RD, Waite AJ, Blake DJ, Veldink JH, Van den Berg LH, Pasterkamp RJ (2015) C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits. Annals of Neurology 78, 426-438.
Parkash J, Messina A, Langlet F, Cimino I, Loyens A, Mazur D, Gallet S, Balland E, Malone SA, Pralong F, Cagnoni G, Schellino R, De Marchis S, Mazzone M, Pasterkamp RJ, Tamagnone L, Prevot V, Giacobini P (2015) Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence. Nature Communications 6, 6385.
Van Battum EY, Brignani S, Pasterkamp RJ (2014). Axon guidance proteins in neurological disease. Lancet Neurology 14, 532-546.
Hessel EV, de Wit M, Wolterink-Donselaar IG, Karst H, de Graaff E, van Lith HA, de Bruijn E, de Sonnaville S, Verbeek NE, Lindhout D, de Kovel CG, Koeleman BP, van Kempen M, Brilstra E, Cuppen E, Loos M, Spijker SS, Kan AA, Baars SE, van Rijen PC, Gosselaar PH, Groot Koerkamp MJ, Holstege FC, van Duijn C, Vergeer J, Moll HA, Taubøll E, Heuser K, Ramakers GM, Pasterkamp RJ, van Nieuwenhuizen O, Hoogenraad CC, Kas MJ, de Graan PN (2015) Identification of Srp9 as a febrile seizure susceptibility gene. Ann Clin Transl Neurol 1, 239-50.
Schmidt ER, Brignani S, Adolfs Y, Lemstra S, Demmers J, Vidaki M, Donahoo AL, Lilleväli K, Vasar E, Richards LJ, Karagogeos D, Kolk SM, Pasterkamp RJ (2014). Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. Neuron 83, 372-387.
Van Battum EY, Gunput RA, Lemstra S, Groen EJ, Yu KL, Adolfs Y, Zhou Y, Hoogenraad CC, Yoshida Y, Schachner M, Akhmanova A, Pasterkamp RJ (2014). The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections. Nature Communications 5, 4317.
Yau KW, Van Beuningen SFB, Cunha-Ferreira I, Cloin BMC, Tas RP, Katrukha EA, Van Battum EY, Schatzle P, Jiang K, Will L, Mikhaylova M, Wulf PS, Harterink M, Pasterkamp RJ, Akhmanova A, Kapitein LC, Hoogenraad CC (2014) Microtubule minus-end binding protein CAMPSAP2 controls axon specification and denrite development. Neuron 82, 1058-1073.
Jaarsma D, Van den Berg R, Wulf PS, Van Erp S, Keijzer N, Schlager MA, De Graaff E, De Zeeuw CI, Pasterkamp RJ, Akhmanova A, Hoogenraad CC (2014). Essential non-cell-autonomous function for Bicaudal-D2 (BICD2) in radial cerebellar granule cell migration. Nature Communications 5, 3411.
Jongbloets BC, Pasterkamp RJ (2014). Semaphorin signaling during development. Development 141, 3292-7.
Diekstra FP, Van Deerlin VM, van Swieten JC, Al-Chalabi A, Ludolph AC, Weishaupt JH, Hardiman O, Landers JE, Brown RH Jr, van Es MA, Pasterkamp RJ, Koppers M, Andersen PM, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, van Damme P, Melki J, Meininger V, Shatunov A, Shaw CE, Leigh PN, Shaw PJ, Morrison KE, Fogh I, Chiò A, Traynor BJ, Czell D, Weber M, Heutink P, de Bakker PI, Silani V, Robberecht W, van den Berg LH, Veldink JH. (2014). C9orf72 and UNC13A are shared risk loci for amyotrophic sclerosis and frontotemporal dementia: A genome-wide meta-analysis. Ann Neurol 76, 120-33.
Van Gestel MA, Van Erp S, Sanders LE, Brans MA, Luijendijk MC, Merkestein M, Pasterkamp RJ, Adan RA (2014). shRNA-induced saturation of the microRNA pathway in the rat brain. Gene Therapy 21, 205-211.
Van den Heuvel DM, Harschnitz O, Van den Berg LH, Pasterkamp RJ (2014). Taking a risk: a therapeutic focus on ataxin-2 in amyotrophic lateral sclerosis? Trends Mol Medicine 20, 25-35.
Manitt C, Eng C, Pokinko M, Ryan RT, Torres-Berrio A, Lopez, JP, Yogendran SV, Daubaras MJ, Grant A, Schmidt ER, Tronche F, Krimpenfort P, Cooper HM, Pasterkamp RJ, Kolb B, Turecki G, Wong TP, Nestler EJ, Giros B, Flores C (2013). DCC orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Transl Psychiatry e338.
Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, Van den Heuvel DM, Koppers M, Van Diggelen F, Van Heest J, Demmers JA, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, Van den Berg LH, Pasterkamp RJ (2013). ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. Hum Mol Genetics 22, 3690-3704.
Bell CH, Healey E, Van Erp S, Bishop B, Tang C, Gilbert RJC, Aricescu AR, Pasterkamp RJ, Siebold C (2013). Structure of the repulsive guidance molecule (RGM)-Neogenin signaling hub. Science 341, 77-80.
Auger ML, Manitt C, Pasterkamp RJ, Flores C (2013). Unc5c haploinsufficienct phenotype: striking similarities with the dcc haploinsufficiency model. Eur J Neurosci 38, 2853-2863.
van der Vaart B, van Riel WE, Doodhi H, Kevenaar JT, Katrukha EA, Gumy L, Bouchet BP, Grigoriev I, Spangler SA, Yu KL, Wulf PS, Wu J, Lansbergen G, van Battum EY, Pasterkamp RJ, Mimori-Kiyosue Y, Demmers J, Olieric N, Maly IV, Hoogenraad CC, Akhmanova A (2013). CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor. Developmental Cell 27, 145-160. F1000
Blokhuis AM, Groen EJ, Koppers M, Van den Berg LH, Pasterkamp RJ (2013). Protein aggregation in ALS. Acta Neuropathologica 125, 777-794.
Manitt C, Eng C, Pokinko M, Ryan RT, Torres-Berrío A, Lopez JP, Yogendran SV, Daubaras MJ, Grant A, Schmidt ER, Tronche F, Krimpenfort P, Cooper HM, Pasterkamp RJ, Kolb B, Turecki G, Wong TP, Nestler EJ, Giros B, Flores C (2013). DCC orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Transl Psychiatry 3, e338.
Van den Heuvel DM, Hellemons AJ, Pasterkamp RJ (2013). Spatiotemporal expression of repulsive axon guidance molecules (RGMs) and their receptor Neogenin in the mouse brain. PloS One 8, e55828.
Blakely BD, Bye CR, Fernando CV, Prasad AA, Pasterkamp RJ, Macheda ML, Stacker SA, Parish C (2013). Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons. Stem Cells Dev 22, 2132-2144.
Kolodkin AL, Pasterkamp RJ (2013). SnapShot: Axon guidance II. Cell 153, 722.
van Spronsen M, van Battum EY, Kuijpers M, Vangoor VR, Rietman ML, Pothof J, Gumy LF, van Ijcken WF, Akhmanova A, Pasterkamp RJ, Hoogenraad CC (2013). Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures. PloS One 8, e74907.
Pasterkamp RJ, Kolodkin AL (2013). SnapShot: Axon guidance I. Cell 153, 494.
Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A (2013). S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodelling factor Brm during radial neuron migration. PNAS 110:3113-318.
Jongbloets BC, Ramakers GM, Pasterkamp RJ (2013). Semaphorin7A and its receptors: pleiotropic regulators of immune cell function, bone homeostasis, and neural development. Semin Cell Dev Biol 24, 129-138.
Koppers M, Groen EJN, Van Vught PWJ, Van Rheenen W, Witteveen E, Van Es MA, Pasterkamp RJ, Van den Berg LH, Veldink JH (2013). Screening for rare variants in the coding region of ALS associated genes at 9p21.2 and 19p13.3. Neurobiology of Aging 34, 1518.e5-7.
Trezza V, Damsteegt R, Manduca A, Van Kerkhof LWM, Pasterkamp RJ, Zhou Y, Campolongo P, Cuomo V, DiMarzo V, Vanderschuren LJ (2012). Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats. J Neurosci 32, 14899-14908.
Pasterkamp RJ (2012). Getting neural circuits into shape with Semaphorins. Nature Reviews Neuroscience 13, 605-618.
Chakrabarty K, Von Oerthel L, Hellemons JCGM, Clotman F, Groot Koerkamp M, Holstege F, Pasterkamp RJ*, Smidt MP* (2012). Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biology Open 1, 693-704. * Shared senior authors.
Kan AA, van Erp S, Derijck AHAA, de Wit M, Hessel EVS, O’Duibhir E, Van Rijen PC, Gosselaar PH, de Graan PNE, Pasterkamp RJ (2012). Genome-wide microRNA profiling of human temporal lobe epilepsy reveals modulators of the immune response. Cell Mol Life Sciences 69, 3127-3145.
Schmidt ER, Morello F, Pasterkamp RJ (2012). Dissection and culture of mouse dopaminergic and striatal explants in three-dimensional collagen matrix assays. J Vis Exp pii 3691.
Blauw HM, van Rheenen W, Koppers M, Van Damme P, Waibel S, Lemmens R, van Vught PW, Meyer T, Schulte C, Gasser T, Cuppen E, Pasterkamp RJ, Robberecht W, Ludolph AC, Veldink JH, van den Berg LH (2012). NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis. Human Molecular Genetics 21, 2497-2502.
Groen EJN, Van Rheenen W, Koppers M, Van Doormaal PTC, Vlam L, Diekstra FP, Doojies D, Pasterkamp RJ, Van den Berg LH, Veldink JH (2012). CGC-repeat expansion in FMR1 is not associated with amyotrophic lateral sclerosis. Neurobiology of Aging 33, 1852.
Koppers M, Van Bitterswijk M, Vlam L, Rowicka P, Van Vught PWJ, Groen EJN, Pasterkamp RJ, Veldink JH, Van den Berg LH (2012). VCP mutations in familial and sporadic amyotrophic lateral sclerosis in the Netherlands. Neurobiology of Aging 33, 837.
Diekstra FP, Van Vught PWJ, Van Rheenen W, Koppers M, Pasterkamp RJ, Van Es MA, Schelhaas HJ, De Visser M, Robberecht W, Andersen PM, Van den Berg LH, Veldink JH (2012). UNC13A is a modifier of survival in amyotrophic lateral sclerosis. Neurobiology of Aging 33, 630.
Zhou Y, Gunput RA, Adolfs Y, Fuller S, Li KW, Van der Schors RC, Smit AB, Sugden P, Hemming B, Hergovich A, Pasterkamp RJ (2011). MICAL-1 is a negative regulator of NDR-MST signaling and apoptosis. Molecular Cellular Biology, 31, 3603-3615.
Van Es MA, Schelhaas HJ, Van Vught PWJ, Andersen PM, Fumoto K, Groen EJN, Blauw HM, Koppers M, Schulte C, Diekstra FP, Bloem BR, Scheffer H, Van Nuenen BFL, Van Blitterswijk M, Van Rheenen W, Van Damme P, Lemmens R, Dahlberg C, Birve A, Fernández-Santiago R, Waibel S, Klein C, Weber M, Van der Kooi AJ, De Visser M, Verbaan D, Van Hilten JJ, Heutink P, Hennekam EAM, Cuppen E, De Bakker PIW, Berg D, Gasser T, Ludolph AC, Robberecht W, Ophoff RA, Veldink JH, Pasterkamp RJ, Van de Warrenburg BP, Van den Berg LH (2011). Rare mutations in ANG confer large risk for ALS and Parkinson’s disease. Ann Neurol 70, 964-973.
Caprini G, Zucchini D, Pasterkamp RJ, Tedischi G, Vanoni M (2011). Kinetic and spectroscopic characterization of the putative monooxygenase domain of human MICAL-1. Arch Biochem Biophys 515, 1-13.
Vorstman JA, van Daalen E, Jalali GR, Schmidt ER, Pasterkamp RJ, de Jonge M, Hennekam EA, Janson E, Staal WG, van der Zwaag B, Burbach JP, Kahn RS, Emanuel BS, van Engeland H, Ophoff RA (2011). A double hit implicates DIAPH3 as an autism risk gene. Mol Psychiatry 16, 442-451.
Messina A, Ferraris N, Cagnoni G, Wray S, Derijck AAH, Adolfs Y, Fasolo A, Pasterkamp RJ, Giacobini P (2011). Semaphorin7A guides migration of GnRH-1 neurons during development. Human Molecular Genetics 20, 4759-4774.
Zhou Y, Gunput RA, Adolfs Y, Pasterkamp RJ (2011). MICALs in control of the cytoskeleton, exocytosis and cell death. Cell Mol Life Sciences 68, 4033-4044.
Grigoriev I, Yu KL, Sanchez-Martinez E, Afonso Serra Marques A, Keijzer N, Demmers J, Peranen J, Pasterkamp RJ, Van der Sluijs P, Hoogenraad CC, Akhmanova A (2011). Rab6 and Rab8 cooperate in controlling docking and fusion of exocytotic carriers. Current Biology 21, 967-974.
Fenstermaker AG, Blokker AA, Bechara A, Adolfs Y, Tissir F, Goffinet A, Zou Y, Pasterkamp RJ (2010). Wnt-Planar Cell Polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem. J Neurosci 30, 16053-16064.
De Backer MWA, Brans MAD, Luijendijk MCM, Garner KM, Van den Heuvel DMA, Pasterkamp RJ, Adan RAH (2010). Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion. BMC Neuroscience 11, 94.
Derijck AAHA, Van Erp S, Pasterkamp RJ (2010). Semaphorin signaling: molecular switches at the midline. Trends Cell Biology 20, 568-576.
Groen EJ, van Es MA, van Vught PW, Spliet WG, van Engelen-Lee J, de Visser M, Wokke JH, Schelhaas HJ, Ophoff RA, Fumoto K, Pasterkamp RJ, Dooijes D, Cuppen E, Veldink JH, van den Berg LH (2010). FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurology 67, 224-230.
Kolk SM, Gunput RA, Tran TS, van den Heuvel DMA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JPH, Smidt MP, Pasterkamp RJ (2009). Semaphorin3F is a bifunctional guidance cue for dopaminergic axons and regulates their fasciculation, channeling, rostral growth and intracortical targeting. J Neurosci 29, 12542-12557.
Van Es MA, Veldink JH, Saris CGJ, Blauw HM, van Vught PWJ, Birve A, Lemmens R, Schelhaas HJ, Groen EJN, Huisman MHB, van der Kooi AJ, de Visser M, Rivadeneira F, Hofman A, Rujescu D, Strengman E, Goldstein D, Muglia P, Slowik A, Uitterlinden AG, Waibel S, Meyer T, Ludolph AC, Glass JD, Purcell S, Landers J, Vermeulen SHM, Kiemeney LA, Wokke JHJ, Cronin S, Hardiman O, Fumoto K, Pasterkamp RJ, Meninger V, Melki J, Leigh PN, Shaw CE, Al-Chalabi A, Brown Jr. RH, Robberecht W, Andersen PM, Ophoff RA, van den Berg LH (2009). Genome-wide association study identifies UNC13A and 9p21.2 as susceptibility loci for sporadic Amyotrophic Lateral Sclerosis. Nature Genetics 41, 1083-1087.
Pasterkamp RJ, Giger RJ (2009). Semaphorin function in neural plasticity and disease. Curr Opinion Neurobiol 19, 263-274.
Degano AL, Pasterkamp RJ, Ronnett GV (2009). MeCP2 deficiency disrupts axonal guidance, fasciculation, and targeting by altering Semaphorin 3F function. Mol Cell Neurosci 42, 243-254.
Schmidt ERE, Pasterkamp RJ*, Van den Berg LH*(2009). Axon guidance proteins: novel therapeutic targets for ALS? Progress Neurobiol 88, 286-301. *Shared senior authors.
Van den Heuvel DMA, Pasterkamp RJ (2008). Getting connected in the dopamine system. Progress Neurobiol 85, 75-93.
Zhou Y, Gunput RA, Pasterkamp RJ (2008). Semaphorin signaling: progress made and future prospects. Trends Biochem Sciences 33, 161-170.
Suzuki K, Yamamoto M, Okuno T, Pasterkamp RJ, Takegahara N, Takamatsu H, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H (2007). Semaphorin 7A initiates T cell-mediated inflammatory responses through alpha1/beta11 integrin. Nature 446, 680-684.
Pasterkamp RJ, Kolk SM, Hellemons AJCGM, Kolodkin AL (2007). Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration. BMC Dev Biol 7, 98.
Pasterkamp RJ, Verhaagen J (2006). Semaphorins in axon regeneration: developmental guidance molecules gone wrong? Royal Soc Phil Trans B 361, 1499-511.
Pasterkamp RJ, Dai HN, Terman JR, Wahlin KJ, Kim B, Bregman BS, Popovich PG, Kolodkin AL (2006). MICAL flavoprotein monooxygenases: expression during neural development and following spinal cord injuries in the at. Mol Cell Neurosci 31, 52-69.
Pasterkamp RJ (2005). R-Ras fills another GAP in Semaphorin signaling. Trends Cell Biol 15, 61-64.
Siebold S, Berrow N, Walter TS, Harlos K, Owens RJ, Stuart DI, Terman JR, Kolodkin AL, Pasterkamp RJ, Jones EY (2005). High-resolution structure of the catalytic region of MICAL, a multi-domain flavoenzyme signaling molecule. PNAS 102, 16836-16841.
Chabbert-de Ponnat I, Marie-Cardine A, Pasterkamp RJ, Schiavon V, Tamagnone L, Thomasset N, Bensussan A, Boumsell L (2005). Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively. Int Immunol 17, 439-447.
Pasterkamp RJ, Kolodkin AL (2003). Semaphorin junction: making tracks toward neural connectivity. Curr Opin Neurobiol 13, 79-89.
Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL (2003). Semaphorin7A promotes axon outgrowth through integrins and MAPKs. Nature 424, 398-405 (article). Preview in Nature.
Terman JR, Mao T, Pasterkamp RJ, Yu H-H, Kolodkin AL (2002). MICALs, a family of conserved oxidoreductases, function in plexin-mediated axonal repulsion. Cell 109, 887-900.
De Winter F, Oudega M, Lankhorst AJ, Hamers FP, Blits B, Ruitenberg MJ, Pasterkamp RJ, Gispen WH, Verhaagen J (2002). Injury induced class 3 semaphorin expression in the rat spinal cord. Exp Neurol 175, 61-75.
Pasterkamp RJ, Verhaagen J (2001). Emerging roles for semaphorins in neural regeneration. Brain Res Rev 35, 36-54.
Pasterkamp RJ, Giger RJ, Baker RE, Hermens WTJMC, Verhaagen J (2000). Ectopic adenoviral vector-directed expression of Sema3A in organotypic spinal cord explants inhibits growth of primary sensory afferents. Dev Biol 220, 129-141.
Pasterkamp RJ, Anderson PN, Verhaagen J (2000). Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin3A. Eur J Neurosci 13, 457-471.
Pasterkamp RJ, Giger RJ, Ruitenberg MJ, Holtmaat AJGD, De Wit J, De Winter F, Verhaagen J (1999). Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS. Mol Cell Neurosci 13, 143-166.
Pasterkamp RJ, Ruitenberg MJ, Verhaagen J (1999). Semaphorins and their receptors in olfactory axon guidance. Cell Mol Biol 45, 763-779.
Pasterkamp RJ, De Winter F, Giger RJ, Verhaagen J (1998). Role for semaphorin(D)III/collapsin-1 in neuronal regeneration and scar formation? Prog Brain Res 117, 151-170.
Pasterkamp RJ, De Winter F, Holtmaat AJGD, Verhaagen J (1998). Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. J Neurosci 18, 9962-9976.
Pasterkamp RJ, Giger RJ, Verhaagen J (1998). Regulation of semaphorinIII/collapsin-1 gene expression during peripheral nerve regeneration. Exp Neurol 153, 313-327.
Giger RJ, Pasterkamp RJ, Heijnen S, Holtmaat AJGD, Verhaagen J (1998). Anatomical distribution of the chemorepellent semaphorinIII/collapsin-1 in the adult rat and human brain: predominant expression in structures of the olfactory-hippocampal pathway and the motor system. J Neurosci Res 52, 27-42.
Dijkhuizen PA, Pasterkamp RJ, Hermens WTJMC, De Winter F, Giger RJ, Verhaagen J (1998). Adenoviral vector-mediated gene delivery to injured rat peripheral nerve. J Neurotrauma 15, 387-397.
Giger RJ, Pasterkamp RJ, Holtmaat AJGD, Verhaagen J (1998). Semaphorin III: role in neuronal development and structural plasticity. Prog Brain Res 117, 134-149.
Pasterkamp RJ, Yuri K, Morita N, Kawata M (1997). Differential expression of estrogen receptor mRNA and protein in the female rat preoptic area. Neurosci Lett 239, 81-84.
Visser DTM, Hu Z, Pasterkamp RJ, Morimoto M, Kawata M (1996). The alteration of glucocorticoid receptor-immunoreactivity in the rat forebrain following short-term and long-term adrenalectomy. Brain Res 729, 216-222.
Pasterkamp RJ, Yuri K, Visser DTM, Hayashi S, Kawata M (1996). The perinatal ontogeny of estrogen receptor-immunoreactivity in the developing male and female rat hypothalamus. Dev Brain Res 9, 300-303.
Pasterkamp RJ, De Winter F, Holtmaat AJGD, Verhaagen J (1998). Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons. J Neurosci 18, 9962-9976.